JOURNAL ARTICLE

Regiodivergent Reactions of 2‐Alkynyl Aziridines with Grignard Reagents.

  • Published In: Advanced Synthesis & Catalysis, 2025, v. 367, n. 7. P. 1 1 of 3

  • Database: Academic Search Ultimate 2 of 3

  • Authored By: Ji, Wen‐Tao; Ping, A‐Nan; Yang, Gaosheng; Chai, Zhuo 3 of 3

Abstract

Herein, we report regiodivergent nucleophilic attack of Grignard reagents to 2‐alkynyl aziridines. Under the catalysis of a Cu(I)‐diphosphine complex, benzylic Grignard reagents add to the carbon‐carbon triple bond of the aziridines to deliver α‐allenylamines in moderate to excellent yields; the direct addition of the Grignard reagents to the aziridines in the absence of catalyst provided homopropargylic amine derivatives. Both reactions could proceed in highly enantiospecific ways. Further synthetic manipulations of these products enable rapid access to diverse useful heterocyclic molecular scaffolds. [ABSTRACT FROM AUTHOR]

Additional Information

  • Source:Advanced Synthesis & Catalysis. 2025/04, Vol. 367, Issue 7, p1
  • Document Type:Article
  • Subject Area:Geology
  • Publication Date:2025
  • ISSN:1615-4150
  • DOI:10.1002/adsc.202401311
  • Accession Number:184320688
  • Copyright Statement:Copyright of Advanced Synthesis & Catalysis is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

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