TITANIUM DIOXIDE NANOPARTICLES PREPARED VIA LASER ABLATION: EVALUATION OF THEIR ANTIBACTERIAL AND ANTICANCER ACTIVITY.

Nanomaterials can be employed in various medicinal industries because of their unique characteristics versus bulk materials. Nanosized particles of Titanium dioxide were fabricated using the laser irradiation technique in this work. After production, the physical properties of Titanium dioxide were identified by Ultraviolet–visible (UV–Vis) spectroscopy, Fourier transform infrared (FTIR) spectrum, X-ray diffraction, FTIR, and Transmission electron microscopy (TEM) techniques. Regarding TEM micrographs with various laser energies, the nanoparticles exhibit a spherical appearance, with average diameters ranging from 19 nm to 26 nm based on the laser energy. X-ray diffraction results from combined Anatase and Rutile crystal structures in the prepared nanoparticles to indicate the production of Titanium dioxide nanoparticles. The FTIR analysis showed that the O-Ti-O mode includes a peak at approximately 480–550 cm − 1 . In this study, the antibacterial efficacy of Titanium dioxide nanoparticles was investigated against Staphylococcus aureus and Escherichia coli, as well as anticancer assay against prostate cancer cell line (PC-3 cells). The result shows that the effectiveness of prepared nanoparticles against S. aureus is more significant than that in E. coli, and the findings indicate the ability of prepared nanoparticles as an antiproliferative agent against PC-3 cells. In conclusion, the prepared nanoparticles could be used as a future strategy for further biomedical applications. [ABSTRACT FROM AUTHOR]