JOURNAL ARTICLE

Iron‐Catalyzed Reductive Coupling of Nitro Compounds with Grignard and Organozinc Reagents for Synthesis of Functionalized Secondary Amines.

  • Published In: Advanced Synthesis & Catalysis, 2025, v. 367, n. 2. P. 1 1 of 3

  • Database: Academic Search Ultimate 2 of 3

  • Authored By: Hata, Takeshi; Nishi, Koki; Goto, Daiki; Tatsumi, Yuta; Kobayashi, Shoma; Shigeta, Masayuki; Urabe, Hirokazu 3 of 3

Abstract

The treatment of nitro compounds with Grignard reagents in the presence of a catalytic amount of FeCl2/t‐BuMgCl produced various types of secondary amines in good yields. This reductive coupling most likely involves the compatibility of functional groups such as chlorine, benzyl ether, olefin, and acetylene. Moreover, the corresponding poly‐substituted amines were not observed under these conditions. When the Grignard reagents were replaced with organozinc reagents, functionalized secondary amines containing ester and nitrile groups were obtained in good yields. [ABSTRACT FROM AUTHOR]

Additional Information

  • Source:Advanced Synthesis & Catalysis. 2025/01, Vol. 367, Issue 2, p1
  • Document Type:Article
  • Subject Area:Geology
  • Publication Date:2025
  • ISSN:1615-4150
  • DOI:10.1002/adsc.202401034
  • Accession Number:183822899
  • Copyright Statement:Copyright of Advanced Synthesis & Catalysis is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

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