Chemical Methods to Identify Epigenetic Modifications in Cytosine Bases.

  • Published In: Chemistry - An Asian Journal, 2024, v. 19, n. 3. P. 1 1 of 3

  • Database: Academic Search Ultimate 2 of 3

  • Authored By: N, Madhumitha; Kumar, Parvathy S.; Manna, Debasish 3 of 3

Abstract

Chemical modifications to Cytosine bases are among the most studied epigenetic markers and their detection in the human genome plays a crucial role in gaining more insights about gene regulation, prognosis of genetic disorders and unraveling genetic inheritance patterns. The Cytosine methylated at the 5th position and oxidized derivatives thereof generated in the demethylation pathways, perform separate and unique epigenetic functions in an organism. As the presence of various Cytosine modifications is associated with diverse diseases, including cancer, there has been a strong focus on developing methods, both chemical and alternative approaches, capable of detecting these modifications at a single‐base resolution across the entire genome. In this comprehensive review, we aim to consolidate the various chemical methods and understanding their chemistry that have been established to date for the detection of various Cytosine modifications. [ABSTRACT FROM AUTHOR]

Additional Information

  • Source:Chemistry - An Asian Journal. 2024/02, Vol. 19, Issue 3, p1
  • Document Type:Literature Review
  • Subject Area:Health and Medicine
  • Publication Date:2024
  • ISSN:1861-4728
  • DOI:10.1002/asia.202301005
  • Accession Number:175417472
  • Copyright Statement:Copyright of Chemistry - An Asian Journal is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

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