JOURNAL ARTICLE

Damage mechanisms of bisphenols on the quality of mammalian oocytes.

  • Published In: Human Reproduction, 2025, v. 40, n. 2. P. 186 1 of 3

  • Database: Academic Search Ultimate 2 of 3

  • Authored By: Pandey, Ashutosh N; Yadav, Pramod K; Premkumar, Karuppanan V; Tiwari, Meenakshi; Antony, Mano Mohan; Pandey, Ajai K; Chaube, Shail K 3 of 3

Abstract

This article focuses on the impact of bisphenol compounds, including bisphenol A (BPA) and its structural analogues, on ovarian function and oocyte quality in mammals, including humans. Bisphenols, widely used as plasticizers, enter the body through dietary and non-dietary routes and induce the generation of reactive oxygen species (ROS), leading to oxidative stress (OS) in the ovary. This OS disrupts folliculogenesis, oogenesis, steroidogenesis, and meiotic processes, triggering cell death pathways in ovarian cells and resulting in follicular atresia, depletion of ovarian reserve, and impaired oocyte quality. The review highlights the need for further research on bisphenol effects at the follicular oocyte level and suggests antioxidant strategies to mitigate reproductive toxicity associated with bisphenol exposure.

Additional Information

  • Source:Human Reproduction. 2025/02, Vol. 40, Issue 2, p186
  • Document Type:Article
  • Subject Area:Health and Medicine
  • Publication Date:2025
  • ISSN:0268-1161
  • DOI:10.1093/humrep/deae284
  • Accession Number:182904945
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