JOURNAL ARTICLE

Exposure to Bisphenol A and Z causes DNA damage and testicular histopathology impairing male fertility.

  • Published In: Toxicology & Industrial Health, 2026, v. 42, n. 5. P. 198 1 of 3

  • Database: Academic Search Ultimate 2 of 3

  • Authored By: ur Rehman, Haseeb; Nadeem, Asif; Mukhtar, Nadia; Ali, Muhammad Muddassir; Mujahid, Huma; Shabbir, Muhammad Zubair; Javed, Maryam 3 of 3

Abstract

This article focuses on the toxic effects of Bisphenol Z (BPZ), a bisphenol analogue, on male reproductive health in Wistar rats. The study found that oral exposure to BPZ at higher doses caused significant reductions in sperm count and motility, abnormal sperm morphology, DNA fragmentation in testicular tissue, and histopathological changes such as narrowing of interstitial spaces and epididymal lumen constriction. Additionally, BPZ exposure led to downregulation of the Protamine1 gene, which is crucial for spermatogenesis. These findings indicate that BPZ exhibits genotoxic and reproductive toxicity comparable to Bisphenol A (BPA), suggesting that bisphenol analogues may pose similar health risks.

Additional Information

  • Source:Toxicology & Industrial Health. 2026/05, Vol. 42, Issue 5, p198
  • Document Type:Article
  • Subject Area:Health and Medicine
  • Publication Date:2026
  • ISSN:0748-2337
  • DOI:10.1177/07482337261438341
  • Accession Number:193124311
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