JOURNAL ARTICLE

X-chromosome inactivation may reduce autism risk.

  • Published In: Mental Health Weekly Digest, 2024. P. 2059 1 of 2

  • Database: Psychology Source 2 of 2

Abstract

A recent study in mice suggests that X-chromosome inactivation may protect girls from a type of autism disorder inherited from their father's X chromosome. Females inherit two copies of the X chromosome, but cells inactivate one copy early in embryonic development. The study found that there is a bias in the process of X-chromosome inactivation, with the paternal X chromosome being inactivated in 60% of cells instead of the expected 50%. This bias may reduce the risk of harmful mutations, which occur more frequently in male chromosomes. The findings may also explain why symptoms of X-linked syndromes, like X-linked autism spectrum disorder, vary more in females than males. [Extracted from the article]

Additional Information

  • Source:Mental Health Weekly Digest. 2024/05, p2059
  • Document Type:Article
  • Subject Area:Health and Medicine
  • Publication Date:2024
  • ISSN:1543-6616
  • Accession Number:177154751
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