A Comparison of Outcomes of Standard Weight-Based and Capped Doses of Albumin for Spontaneous Bacterial Peritonitis.

This study evaluates the impact of capped versus weight-based intravenous albumin dosing on renal outcomes in patients with cirrhosis treated for spontaneous bacterial peritonitis (SBP). Comparing a capped dose of 100 g or less to doses exceeding 100 g, the retrospective analysis found no significant differences in rates of acute kidney injury (AKI) at day 5, SBP resolution, or mortality at days 5 and 30. The capped dosing strategy was associated with substantial cost savings without compromising clinical outcomes. These findings suggest that limiting albumin doses to 100 g may be an effective and resource-conscious approach in managing SBP, though further research is needed to assess potential effects on adverse events such as fluid overload.