JOURNAL ARTICLE

Host stress hormone norepinephrine reduces in vitro activity of aminoglycoside against carbapenemase-producing Enterobacterales.

  • Published In: Journal of Antimicrobial Chemotherapy (JAC), 2024, v. 79, n. 6. P. 1468 1 of 3

  • Database: Academic Search Ultimate 2 of 3

  • Authored By: Inaba, Masato; Doi, Yohei 3 of 3

Abstract

This article discusses the impact of the stress hormone norepinephrine (NE) on the activity of antibiotics against carbapenemase-producing Enterobacterales (CPE), a highly drug-resistant pathogen. The study found that NE enhances biofilm formation and reduces the effectiveness of aminoglycoside antibiotics against CPE. These findings suggest that elevated NE levels in severely ill patients may compromise the efficacy of antibiotic therapy for CPE infections, even when the infecting strain appears susceptible based on standard susceptibility testing. The study highlights the importance of considering physiological stress responses in the management of drug-resistant infections. [Extracted from the article]

Additional Information

  • Source:Journal of Antimicrobial Chemotherapy (JAC). 2024/06, Vol. 79, Issue 6, p1468
  • Document Type:Article
  • Subject Area:Health and Medicine
  • Publication Date:2024
  • ISSN:0305-7453
  • DOI:10.1093/jac/dkae113
  • Accession Number:177611560
  • Copyright Statement:Copyright of Journal of Antimicrobial Chemotherapy (JAC) is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

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