JOURNAL ARTICLE

Diagnostic work-up of ACTH-dependent Cushing's syndrome in the context of CRH shortage: recommendation of a task force from the European Society of Endocrinology.

  • Published In: European Journal of Endocrinology, 2024, v. 191, n. 1. P. R32 1 of 3

  • Database: Academic Search Ultimate 2 of 3

  • Authored By: Colao, Annamaria; Scaroni, Carla; Mezösi, Emese; Saiegh, Leonard; Puig-Domingo, Manel; Marques, Pedro; Deutschbein, Timo 3 of 3

Abstract

The article discusses the recent discontinuation of corticotropin-releasing hormone (CRH) production by the main global supplier and the implications for diagnosing adrenocorticotropic hormone (ACTH)-dependent Cushing's syndrome. In response, the European Society of Endocrinology has formed a task force to recommend alternative diagnostic tests, including the desmopressin test, high dose dexamethasone suppression test, pituitary magnetic resonance imaging (MRI), and whole-body computed tomography. The article emphasizes the importance of combining these tests to enhance diagnostic accuracy, particularly when CRH is unavailable, and suggests that inferior petrosal sinus sampling with desmopressin may be considered if other tests yield inconclusive results. [Extracted from the article]

Additional Information

  • Source:European Journal of Endocrinology. 2024/07, Vol. 191, Issue 1, pR32
  • Document Type:Article
  • Subject Area:Health and Medicine
  • Publication Date:2024
  • ISSN:0804-4643
  • DOI:10.1093/ejendo/lvae073
  • Accession Number:178778945
  • Copyright Statement:Copyright of European Journal of Endocrinology is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

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