Identification of a novel B allele with a c.145C>T variant.

Most ABO subtype-relevant nucleotide missense variants have been identified in the last two exons (6 and 7) of the I ABO i gene, which encode 91% of the catalytic domain of ABO glycosyltransferases.[[1]] Here, we report a novel missense variant (c.145C>T, p.Arg49Trp) in exon 3 on the I ABO*B.01 i allele, first identified in a Chinese individual with AB SB 3 sb phenotype. Keywords: ABO; new allele EN ABO new allele E40 E42 3 08/16/23 20230801 NES 230801 Abbreviations AA amino acid mf mixed-field RBC red blood cell SHPBC Shanghai Hemo-Pharmaceutical Biological Company BACKGROUND The ABO blood group system is the most clinically relevant in both transfusion and transplantation medicine. BRIEF SUMMARY In conclusion, a novel I B i allele with c.145C>T in exon 3 on the I ABO*B.01 i allele was identified. [Extracted from the article]