JOURNAL ARTICLE

Human fallopian tube organoids provide a favourable environment for sperm motility.

  • Published In: Human Reproduction, 2025, v. 40, n. 3. P. 503 1 of 3

  • Database: Academic Search Ultimate 2 of 3

  • Authored By: Gatimel, Nicolas; Perez, Guillaume; Bruno, Eloïse; Sagnat, David; Rolland, Corinne; Tanguy-Le-Gac, Yan; Donato, Emeline Di; Racaud, Claire; Léandri, Roger; Bettiol, Célia; Deraison, Céline; Motta, Jean-Paul; Huyghe, Eric; Vergnolle, Nathalie 3 of 3

Abstract

This article focuses on the development and characterization of a human fallopian tube (HFT) organoid model to evaluate its capacity to support human sperm survival and motility. Derived from adult stem cells of the isthmus and ampulla regions of fallopian tubes from 10 donor patients, these organoids exhibited differentiated ciliated and secretory epithelial cells and responded to hormonal stimuli, closely mimicking in vivo tissue characteristics. Functional assays demonstrated that the apical compartment of differentiated HFT organoids provided a more favorable environment for maintaining sperm motility and kinematic parameters over 96 hours compared to commercial sperm media and control conditions, including colon organoids. This model offers a novel in vitro platform for studying tubal physiology and gamete-epithelium interactions, with potential implications for improving assisted reproductive technologies by enhancing gamete handling and embryo culture conditions.

Additional Information

  • Source:Human Reproduction. 2025/03, Vol. 40, Issue 3, p503
  • Document Type:Article
  • Subject Area:Health and Medicine
  • Publication Date:2025
  • ISSN:0268-1161
  • DOI:10.1093/humrep/deae258
  • Accession Number:184297452
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