JOURNAL ARTICLE

LGR5 Expression Is Associated With Prognosis in High-Grade Hepatocellular Carcinoma.

  • Published In: International Journal of Surgical Pathology, 2026, v. 34, n. 2. P. 407 1 of 3

  • Database: Academic Search Ultimate 2 of 3

  • Authored By: Sugenoya, Shinsuke; Uehara, Takeshi; Iwaya, Mai; Asaka, Shiho; Nakajima, Tomoyuki; Komamura, Shotaro; Sawaguchi, Hiroshi; Imamura, Shunsuke; Yoshizawa, Takahiro; Shimizu, Akira; Ota, Hiroyoshi; Soejima, Yuji 3 of 3

Abstract

This article focuses on the expression and prognostic significance of leucine-rich repeat-containing G protein-coupled receptor 5 (LGR5), a cancer stem cell marker, in hepatocellular carcinoma (HCC). Using RNAscope, a sensitive RNA in situ hybridization technique, LGR5 expression was analyzed in tumor centers and invasion fronts of 36 patients with primary solitary HCC. High LGR5 expression at the tumor center was significantly associated with high-grade tumors and shorter recurrence-free survival, while expression at the invasion front correlated with high-grade tumors and larger tumor size but showed no prognostic significance. These findings suggest that LGR5 expression may serve as a prognostic marker for recurrence risk in high-grade HCC, although further studies are needed to clarify its molecular role and potential as a therapeutic target.

Additional Information

  • Source:International Journal of Surgical Pathology. 2026/04, Vol. 34, Issue 2, p407
  • Document Type:Article
  • Subject Area:Health and Medicine
  • Publication Date:2026
  • ISSN:1066-8969
  • DOI:10.1177/10668969251384894
  • Accession Number:191423588
  • Copyright Statement:Copyright of International Journal of Surgical Pathology is the property of Sage Publications Inc. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

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