JOURNAL ARTICLE

NLRP3 missense variant may contribute to dermatophytosis susceptibility.

  • Published In: Journal of the European Academy of Dermatology & Venereology, 2025, v. 39, n. 10. P. e922 1 of 3

  • Database: Academic Search Ultimate 2 of 3

  • Authored By: Blanchard, Gabriela; Blanchard, Maël; Prompsy, Pacôme; Fratti, Marina; Xenarios, Ioannis; Shevrikuko, Arkadiy; Salamin, Karine; Monod, Michel; Guenova, Emmanuella 3 of 3

Abstract

The article focuses on the association between a specific genetic variant in the NLRP3 gene and susceptibility to dermatophytosis, a common fungal skin infection. A case study is presented involving a mother and son with a history of onychomycosis and tinea pedis, where whole exome sequencing revealed a missense variant (c.2113C>A, Q705K) in NLRP3, which was not found in the father. The NLRP3 inflammasome is implicated in the immune response to dermatophyte infections, and the identified variant may lead to increased IL-1β production, potentially heightening the risk of fungal infections. The study suggests that NLRP3 should be included in genetic testing panels for dermatophytosis susceptibility. [Extracted from the article]

Additional Information

  • Source:Journal of the European Academy of Dermatology & Venereology. 2025/10, Vol. 39, Issue 10, pe922
  • Document Type:Article
  • Subject Area:Health and Medicine
  • Publication Date:2025
  • ISSN:0926-9959
  • DOI:10.1111/jdv.20658
  • Accession Number:188293566
  • Copyright Statement:Copyright of Journal of the European Academy of Dermatology & Venereology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

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