JOURNAL ARTICLE

The HPV16 E6, E7/miR-23b-3p/ICAT signaling axis promotes proliferation, migration, invasion and EMT of cervical cancer cells.

  • Published In: Carcinogenesis, 2023, v. 44, n. 3. P. 221 1 of 3

  • Database: Academic Search Ultimate 2 of 3

  • Authored By: Hu, Jing; Liao, Deyu; Sun, Zijiu; Ren, Wei; Zhao, Ling; Fang, Yuting; Hu, Kai; Yu, Huomei; Liu, Shiyan; Zhou, Lan; He, Tongchuan; Zhang, Yan 3 of 3

Abstract

This article investigates the molecular mechanism by which the human papillomavirus type 16 (HPV16) oncoproteins E6 and E7 contribute to the progression of cervical cancer (CC). It demonstrates that HPV16 E6 and E7 downregulate the tumor-suppressive microRNA miR-23b-3p, leading to increased expression of the inhibitor of β-catenin and transcription factor (ICAT), which promotes CC cell proliferation, migration, invasion, and epithelial-mesenchymal transition (EMT). Functional assays showed that miR-23b-3p directly targets ICAT to suppress malignant behaviors in HPV16-positive CC cell lines, while ICAT overexpression reverses these effects. The study identifies the HPV16 E6/E7–miR-23b-3p–ICAT regulatory axis as a potential therapeutic target for HPV16-associated cervical cancer.

Additional Information

  • Source:Carcinogenesis. 2023/03, Vol. 44, Issue 3, p221
  • Document Type:Article
  • Subject Area:Health and Medicine
  • Publication Date:2023
  • ISSN:0143-3334
  • DOI:10.1093/carcin/bgad008
  • Accession Number:163956869
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