JOURNAL ARTICLE

Characterization of iso-LSD metabolism using human liver microsomes in comparison to LSD and its applicability as urinary biomarker for LSD consumption.

  • Published In: Journal of Analytical Toxicology, 2024, v. 48, n. 5. P. 281 1 of 3

  • Database: Academic Search Ultimate 2 of 3

  • Authored By: Ng, Xue Qin; Goh, Evelyn Mei Ling; Hamzah, Asimah; Yao, Yi Ju; Moy, Hooi Yan 3 of 3

Abstract

This article focuses on the metabolism and urinary detection of iso-lysergic acid diethylamide (iso-LSD), a diastereomer and contaminant of illicitly synthesized lysergic acid diethylamide (LSD). The study demonstrates that iso-LSD is metabolized more slowly than LSD in human liver microsomes and is frequently detected in urine samples, sometimes even in the absence of LSD and its primary metabolite, 2-oxo-3-hydroxy-LSD. Iso-LSD and its metabolites, including a newly identified 2-oxo-3-hydroxy-iso-LSD, show potential as viable urinary biomarkers for confirming LSD consumption. The findings suggest that toxicology laboratories should differentiate iso-LSD from LSD in analyses to avoid misidentification and improve detection accuracy in forensic and clinical settings.

Additional Information

  • Source:Journal of Analytical Toxicology. 2024/06, Vol. 48, Issue 5, p281
  • Document Type:Article
  • Subject Area:Health and Medicine
  • Publication Date:2024
  • ISSN:0146-4760
  • DOI:10.1093/jat/bkae023
  • Accession Number:177948137
  • Copyright Statement:Copyright of Journal of Analytical Toxicology is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

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