JOURNAL ARTICLE

Ivermectin-Based Products in the Context of Green Pharmaceutical Analysis.

  • Published In: Journal of AOAC International, 2025, v. 108, n. 1. P. 123 1 of 3

  • Database: Academic Search Ultimate 2 of 3

  • Authored By: Galvão, Natália Sabina dos Santos; Kogawa, Ana Carolina 3 of 3

Abstract

This article reviews existing analytical methods for evaluating ivermectin (IVE), a broad-spectrum antiparasitic used in human and veterinary medicine, focusing on their alignment with green analytical chemistry (GAC) principles. It finds that most methods, predominantly high performance liquid chromatography (HPLC), rely heavily on harmful solvents such as acetonitrile and methanol, which pose environmental and health risks. Various greenness assessment tools—National Environmental Method Index (NEMI), Eco-Scale Assessment (ESA), Analytical GREEnness Metric (AGREE), and Green Analytical Procedure Index (GAPI)—reveal inconsistencies in evaluating these methods’ eco-efficiency, with many not fully complying with GAC principles. The review highlights the need and opportunity to develop more sustainable, eco-friendly analytical methods for ivermectin quality control in pharmaceutical products.

Additional Information

  • Source:Journal of AOAC International. 2025/01, Vol. 108, Issue 1, p123
  • Document Type:Article
  • Subject Area:Health and Medicine
  • Publication Date:2025
  • ISSN:1060-3271
  • DOI:10.1093/jaoacint/qsae072
  • Accession Number:182534533
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