JOURNAL ARTICLE

eccDNA Atlas: a comprehensive resource of eccDNA catalog.

  • Published In: Briefings in Bioinformatics, 2023, v. 24, n. 2. P. 1 1 of 3

  • Database: Academic Search Ultimate 2 of 3

  • Authored By: Zhong, Tengwei; Wang, Wenqing; Liu, Houyan; Zeng, Maolin; Zhao, Xinyu; Guo, Zhiyun 3 of 3

Abstract

The article focuses on the development of eccDNA Atlas, an integrated and user-friendly database for extrachromosomal circular DNA (eccDNA) and extrachromosomal DNA (ecDNA) across multiple species. eccDNA Atlas compiles 629,987 eccDNAs and 8,221 ecDNAs manually curated from 3,636 literatures, along with 1,105 ecDNAs predicted from whole-genome sequencing (WGS) data of 319 tumor samples using the AmpliconArchitect tool. The database provides comprehensive annotations—including oncogenes, enhancers, SNPs, chromatin accessibility, and eQTLs—and offers utilities for browsing, searching, analysis, genome visualization, and data submission. This resource aims to facilitate research on the characteristics and functions of eccDNAs/ecDNAs in health and disease by consolidating fragmented data and enabling customized analyses.

Additional Information

  • Source:Briefings in Bioinformatics. 2023/03, Vol. 24, Issue 2, p1
  • Document Type:Article
  • Subject Area:Health and Medicine
  • Publication Date:2023
  • ISSN:1467-5463
  • DOI:10.1093/bib/bbad037
  • Accession Number:162589460
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