JOURNAL ARTICLE

Efficacy and Safety of Moxidectin-Albendazole and Ivermectin-Albendazole Combination Therapy Compared to Albendazole Monotherapy in Adolescents and Adults Infected with Trichuris trichiura: A Randomized, Controlled Superiority Trial.

  • Published In: Clinical Infectious Diseases, 2023, v. 77, n. 9. P. 1294 1 of 3

  • Database: Academic Search Ultimate 2 of 3

  • Authored By: Sprecher, Viviane P; Coulibaly, Jean T; Hürlimann, Eveline; Hattendorf, Jan; Keiser, Jennifer 3 of 3

Abstract

This article focuses on a randomized, placebo-controlled trial conducted in Côte d'Ivoire to evaluate the efficacy and safety of moxidectin-albendazole combination therapy compared to albendazole monotherapy and ivermectin-albendazole combination for treating Trichuris trichiura infection, a soil-transmitted helminth. The study found no significant superiority of moxidectin-albendazole or ivermectin-albendazole over albendazole alone, with low cure rates of 15.3%, 22.5%, and 13.4%, respectively. All treatments were generally well tolerated with mostly mild and transient adverse events. The findings highlight the need for alternative treatment options and further research to understand the limited efficacy of current therapies against trichuriasis in this setting.

Additional Information

  • Source:Clinical Infectious Diseases. 2023/11, Vol. 77, Issue 9, p1294
  • Document Type:Article
  • Subject Area:Health and Medicine
  • Publication Date:2023
  • ISSN:1058-4838
  • DOI:10.1093/cid/ciad387
  • Accession Number:173554383
  • Copyright Statement:Copyright of Clinical Infectious Diseases is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

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