Some Polyphenolic Compounds as Potential Therapeutic Agents in Cervical Cancer: The Most Recent Advances and Future Prospects.

This article reviews the potential anticancer effects of dietary polyphenols on cervical cancer (CC), focusing on their molecular mechanisms, safety, and therapeutic prospects. Polyphenols, including stilbenes like resveratrol and pterostilbene, and flavonoids such as quercetin, apigenin, fisetin, naringin, and naringenin, have demonstrated abilities to inhibit CC cell proliferation, induce apoptosis, and interfere with human papillomavirus (HPV)-related oncogenic pathways in various in vitro, animal, and limited human studies. Tea polyphenols (e.g., epigallocatechin gallate) and curcumin also show chemopreventive properties by modulating signaling pathways involved in cancer progression. While polyphenols are generally safe and cost-effective, the article emphasizes the need for more extensive clinical trials to clarify optimal dosages, bioavailability, drug–nutrient interactions, and long-term safety before recommending their medicinal use in CC treatment.