JOURNAL ARTICLE

A - 95 De Novo Impulse Control Symptoms in Parkinson's Disease Patients Undergoing GPi-DBS: a Prospective Study.

  • Published In: Archives of Clinical Neuropsychology, 2024, v. 39, n. 7. P. 1033 1 of 3

  • Database: Academic Search Ultimate 2 of 3

  • Authored By: Combs, Hannah L; York, Michele K; Jimenez-Shahed, Joohi 3 of 3

Abstract

This study focuses on the development of de novo impulse control disorders (ICDs) in Parkinson’s disease (PD) patients undergoing deep brain stimulation (DBS) targeting either the globus pallidus interna (GPi) or the subthalamic nucleus (STN). In a prospective analysis of 27 PD patients, those receiving GPi-DBS were more likely to develop new ICD symptoms post-surgery compared to those receiving STN-DBS, despite similar neurocognitive outcomes between groups. Preoperatively, ICD prevalence was higher in the STN-DBS group, but postoperatively, 80% of GPi-DBS patients exhibited ICDs versus 35% of STN-DBS patients. These findings suggest a distinct neuropsychiatric risk profile associated with GPi-DBS, underscoring the need for further research into its underlying neural mechanisms.

Additional Information

  • Source:Archives of Clinical Neuropsychology. 2024/10, Vol. 39, Issue 7, p1033
  • Document Type:Abstract
  • Subject Area:Health and Medicine
  • Publication Date:2024
  • ISSN:0887-6177
  • DOI:10.1093/arclin/acae067.109
  • Accession Number:184163400
  • Copyright Statement:Copyright of Archives of Clinical Neuropsychology is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

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