Ossification and Bone Regeneration in a Canine GBR Model, Part 2: Glycated Cross-Linked Collagenated Alloplastic Hydroxyapatite Scaffold vs Non-Cross-Linked Collagenated Xenographic Bone Hydroxyapatite.

This article focuses on comparing two bone graft substitutes—OSSIX Bone (OB), a glycated cross-linked collagenated alloplastic hydroxyapatite scaffold, and Bio-Oss Collagen (BOC), a non–cross-linked collagenated xenographic bovine-derived hydroxyapatite—in a canine guided bone regeneration (GBR) model. Using bilateral mandibular defects in 19 Beagle dogs, the study evaluated bone volume, mineral density, histology, and ridge restoration at 4, 12, and 24 weeks post-surgery. Both OB and BOC demonstrated similar biocompatibility and effectively promoted bone regeneration and alveolar ridge restoration compared to untreated controls, with OB showing greater dimensional stability and wider alveolar ridge widths at 24 weeks. The findings suggest that both graft materials are valid options for treating critical-sized bone defects, with differences in resorption and remodeling kinetics reflecting their distinct compositions.