JOURNAL ARTICLE

Evaluating the Readability of the iPledge Comprehension Assessment and its Impact on Isotretinoin Accessibility.

  • Published In: Pediatric Dermatology, 2025, v. 42, n. 2. P. 413 1 of 3

  • Database: Academic Search Ultimate 2 of 3

  • Authored By: Baek, Peter; Shah, Nidhi; Kirkorian, A. Yasmine 3 of 3

Abstract

Isotretinoin, the standard treatment for severe nodular acne, is subject to stringent iPLEDGE regulations due to its teratogenic risks, requiring monthly assessments for patients of childbearing potential. Analysis of the iPLEDGE Comprehension Assessment (iPCA) revealed an average readability score of grade 8.5, exceeding the recommended grade 6 level for optimal patient comprehension. The complex language of iPCA may hinder patients from accessing treatment, contributing to delays and potential discontinuation, especially among female patients. While the overall number of isotretinoin‐exposed pregnancies has decreased since the inception of iPledge, several hundred pregnancies continue to be reported, and simplification of iPCA presents one avenue to improve patient comprehension, safety, and ensuring equitable access to isotretinoin. [ABSTRACT FROM AUTHOR]

Additional Information

  • Source:Pediatric Dermatology. 2025/03, Vol. 42, Issue 2, p413
  • Document Type:Article
  • Subject Area:Health and Medicine
  • Publication Date:2025
  • ISSN:0736-8046
  • DOI:10.1111/pde.15765
  • Accession Number:184140296
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