JOURNAL ARTICLE

Inhibition of Indirect Pathway Activity Causes Abnormal Decision-Making In a Mouse Model of Impulse Control Disorder in Parkinson's Disease (Updated February 23, 2024).

  • Published In: Mental Health Weekly Digest, 2024. P. 3091 1 of 2

  • Database: Psychology Source 2 of 2

Abstract

A recent preprint abstract discusses a study that developed a mouse model of impulse control disorder (ICD) in Parkinson's disease (PD). The researchers found that in parkinsonian mice, the dopamine agonist pramipexole led to more pronounced delay discounting and disrupted firing in both direct and indirect pathway neurons. Additionally, chemogenetic inhibition of indirect pathway neurons in parkinsonian mice produced similar phenotypes. These findings provide new insights into the pathophysiology of ICD in PD. However, it is important to note that this preprint has not yet undergone peer review. [Extracted from the article]

Additional Information

  • Source:Mental Health Weekly Digest. 2024/03, p3091
  • Document Type:Article
  • Subject Area:Health and Medicine
  • Publication Date:2024
  • ISSN:1543-6616
  • Accession Number:175910410
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