JOURNAL ARTICLE

In vivo evaluation of cefazolin inoculum effect in the treatment of experimental Staphylococcus aureus pneumonia with cefazolin.

  • Published In: Journal of Antimicrobial Chemotherapy (JAC), 2025, v. 80, n. 5. P. 1287 1 of 3

  • Database: Academic Search Ultimate 2 of 3

  • Authored By: Lee, Soon Ok; Lee, Shinwon; Park, Sohee; Lee, Jeong Eun; Lee, Sun Hee 3 of 3

Abstract

This study investigates the impact of the cefazolin inoculum effect (CIE) on the efficacy of cefazolin in treating pneumonia caused by methicillin-susceptible Staphylococcus aureus (MSSA) using a mouse model. CIE refers to reduced susceptibility of MSSA to cefazolin at high bacterial loads, linked to β-lactamase production, particularly type A blaZ-positive strains. The research compared a CIE-positive MSSA strain with its blaZ gene-eliminated (CIE-negative) derivative, finding that cefazolin was less effective in reducing bacterial loads and preventing metastatic infections in CIE-positive infections, whereas oxacillin remained effective regardless of CIE status. These results suggest that CIE may compromise cefazolin treatment in severe MSSA infections, highlighting the need for cautious use of cefazolin in high-burden cases.

Additional Information

  • Source:Journal of Antimicrobial Chemotherapy (JAC). 2025/05, Vol. 80, Issue 5, p1287
  • Document Type:Article
  • Subject Area:Health and Medicine
  • Publication Date:2025
  • ISSN:0305-7453
  • DOI:10.1093/jac/dkaf065
  • Accession Number:185320608
  • Copyright Statement:Copyright of Journal of Antimicrobial Chemotherapy (JAC) is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

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