EEG Reveals Alterations in Motor Imagery in People With Amnestic Mild Cognitive Impairment.

This article investigates motor imagery deficits in people with amnestic mild cognitive impairment (aMCI) using electroencephalography (EEG) during a hand laterality judgment task (HLJT). The study found that while both aMCI and healthy controls accurately represented visual imagery (VI)-related orientation features, individuals with aMCI showed impaired neural representation of kinesthetic imagery (KI)-related biomechanical features, indicating deficits in automatic activation of KI strategies. EEG activity differences in posterior–parietal and frontal brain regions were associated with cognitive functions including episodic memory, visuospatial ability, and executive function, with response time mediating the relationship between biomechanical feature representation and executive function in aMCI. These findings suggest that EEG indices related to motor imagery may serve as potential biomarkers for cognitive impairment in the Alzheimer's disease continuum.