JOURNAL ARTICLE

A Prospective Multicenter Observational Study Investigating the Concordance Between Patient-Reported Hearing Loss and Commonly Used Ototoxicity Grading Systems in Patients Treated with Platinum-Based Chemotherapy.

  • Published In: Annals of Otology, Rhinology & Laryngology, 2026, v. 135, n. 6. P. 443 1 of 3

  • Database: Academic Search Ultimate 2 of 3

  • Authored By: Burger, Anouk V. M.; Duinkerken, Charlotte W.; Theunissen, Eleonoor A. R.; Schaeffers, Anouk W. M. A.; Hauptmann, Michael; Hoetink, Alexander E.; Balm, Alfons J. M.; de Boer, Jan Paul; Maas-Bannink, Esther; Exterkate, Leonie; Slingerland, Marije; Jansen, Jeroen C.; Stokroos, Robert J.; de Bree, Remco; Devriese, Lot A.; Dreschler, Wouter A.; Bruintjes, Tjasse D.; van Sluis, Klaske E.; Zuur, Charlotte L. 3 of 3

Abstract

This study compares the accuracy of three ototoxicity grading systems—TUNE, American Speech-Language-Hearing Association (ASHA), and Common Terminology Criteria for Adverse Events (CTCAE)—in reflecting the severity of hearing loss related to platinum-based chemotherapy, using pure-tone audiometry and patient-reported outcomes measured by the Speech, Spatial, and Qualities of Hearing scale compare questionnaire (SSQ). Conducted prospectively across three Dutch cancer centers from 2018 to 2024 with 74 eligible patients, the study found that the TUNE criteria, which incorporate both standard and extended high-frequency audiometry, showed higher concordance (81%) and a stronger statistically significant correlation with patient-reported hearing loss than the CTCAE (73%) and ASHA (68%) criteria. The findings suggest that TUNE better captures the functional impact of hearing loss in daily life for patients treated with cisplatin, supporting its use over the other grading systems in clinical and research settings.

Additional Information

  • Source:Annals of Otology, Rhinology & Laryngology. 2026/06, Vol. 135, Issue 6, p443
  • Document Type:Article
  • Subject Area:Health and Medicine
  • Publication Date:2026
  • ISSN:0003-4894
  • DOI:10.1177/00034894251408705
  • Accession Number:193319953
  • Copyright Statement:Copyright of Annals of Otology, Rhinology & Laryngology is the property of Sage Publications Inc. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

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