JOURNAL ARTICLE

Anaphylactic shock due to dextromethorphan confirmed by a drug provocation test despite negative SPT and BAT results.

  • Published In: Pediatrics International, 2025, v. 67, n. 1. P. 1 1 of 3

  • Database: Academic Search Ultimate 2 of 3

  • Authored By: Kajita, Naoki; Yoshida, Koichi 3 of 3

Abstract

The article focuses on a case of a 14-year-old female patient who experienced anaphylactic shock after taking dextromethorphan (DXM), a common nonopioid antitussive drug. Despite having taken DXM and other medications previously without issues, she developed severe symptoms, including generalized erythema and hives, shortly after her first dose. Diagnosis of DXM-induced anaphylaxis was confirmed through a drug provocation test (DPT), which showed positive results for DXM while skin prick tests (SPT) and basophil activation tests (BAT) yielded inconsistent findings. The case highlights the importance of DPT as the gold standard for diagnosing drug hypersensitivity, especially when other allergy tests do not align. [Extracted from the article]

Additional Information

  • Source:Pediatrics International. 2025/01, Vol. 67, Issue 1, p1
  • Document Type:Article
  • Subject Area:Health and Medicine
  • Publication Date:2025
  • ISSN:1328-8067
  • DOI:10.1111/ped.70036
  • Accession Number:190445086
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