JOURNAL ARTICLE

Impact of low- or moderate-risk gonadotoxic chemotherapy prior to testicular tissue freezing on spermatogonia quantity in human (pre)pubertal testicular tissue.

  • Published In: Human Reproduction, 2023, v. 38, n. 11. P. 2105 1 of 3

  • Database: Academic Search Ultimate 2 of 3

  • Authored By: Feraille, Aurélie; Liard, Agnès; Rives, Nathalie; Bubenheim, Michael; Barbotin, Anne-Laure; d'Estaing, Sandrine Giscard; Mirallié, Sophie; Ancelle, Amélie; Roux, Christophe; Brugnon, Florence; Daudin, Myriam; Schneider, Pascale; Dumont, Ludovic; Rondanino, Christine 3 of 3

Abstract

This article investigates the impact of low- or moderate-risk gonadotoxic chemotherapy and cancer itself on spermatogonia quantity in testicular tissue from (pre)pubertal boys undergoing testicular tissue freezing (TTF) for fertility preservation. The study analyzed testicular samples from 79 boys aged 6 months to 16 years, finding that alkylating agents significantly reduce spermatogonia numbers, with a sharp decline when the cyclophosphamide equivalent dose (CED) exceeds 4000 mg/m². Vincristine, when combined with alkylating agents, showed an additional adverse effect on spermatogonial quantity, whereas carboplatin alone did not demonstrate a significant impact compared to non-alkylating chemotherapy. The findings support proposing TTF before highly gonadotoxic treatments with predicted CED above 4000 mg/m², though further research is needed to confirm the effects of vincristine and carboplatin.

Additional Information

  • Source:Human Reproduction. 2023/11, Vol. 38, Issue 11, p2105
  • Document Type:Article
  • Subject Area:Health and Medicine
  • Publication Date:2023
  • ISSN:0268-1161
  • DOI:10.1093/humrep/dead161
  • Accession Number:173398688
  • Copyright Statement:Copyright of Human Reproduction is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Looking to go deeper into this topic? Look for more articles on EBSCOhost.