A modern molecular mechanism for an ancient psychoactive substance: TMEM132B as a novel protein controlling alcohol actions in the brain.

  • Published In: Neuroscientist, 2025, v. 31, n. 2. P. 121 1 of 2

  • Database: Academic Search Ultimate 2 of 2

Abstract

The article discusses the molecular mechanism of alcohol's effects on the brain, focusing on the role of the TMEM132B protein as a GABAA auxiliary subunit. Through experiments on human and mouse brain tissue, researchers found that TMEM132B interacts with GABAA receptors, influencing the anxiolytic and sedative properties of alcohol. The study suggests that targeting TMEM132B could be a potential treatment for alcohol use disorder, epilepsy, and other GABAA-related conditions. [Extracted from the article]

Additional Information

  • Source:Neuroscientist. 2025/04, Vol. 31, Issue 2, p121
  • Document Type:Article
  • Subject Area:Health and Medicine
  • Publication Date:2025
  • ISSN:1073-8584
  • DOI:10.1177/10738584251327384
  • Accession Number:183686969
  • Copyright Statement:Copyright of Neuroscientist is the property of Sage Publications Inc. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Looking to go deeper into this topic? Look for more articles on EBSCOhost.