DEVELOPMENT AND CHARACTERISATION OF METHYL ESTER DERIVATIVES OF PARA-AMINOBENZOIC ACID FOR PHARMACEUTICAL APPLICATIONS.

In pharmaceuticals, para-aminobenzoic acid (PABA) methyl ester was developed and characterised in the present study. A versatile precursor to chemical transformations, esterification reactions included, PABA is a water soluble form of B complex vitamin. PABA is made into methyl esters via esterification with methanol by concentrated sulphuric acid. The esterification process enhances the compound's lipophilicity and membrane permeability, showing promise for pharmaceutical delivery system, in fighting with the limitations in bioavailability. Based on a series of analytical techniques such as FTIR spectroscopy, UV-Vis. spectroscopy, NMR spectroscopy, and melting point determination, the synthesised methyl ester is characterised. Esterification is confirmed and structure insight is given to the compound's functional group and purity. The solubility profile points to high solubility in polar organic solvents like methanol and ethanol making them drug formable. Studies of stability under a number of different pH conditions indicate that this methyl ester is stable under neutral conditions and subject to hydrolysis in acidic environments, which may be useful in the design of targeted delivery systems. Overall, this supports establishing PABA methyl ester as a prodrug or active pharmaceutical ingredient for controlled release, and it is a good pharmaceutical formulation development candidate. [ABSTRACT FROM AUTHOR]