A Randomized Controlled Study on the Therapeutic Effects of Doxofylline Combined with Erchen Decoction in COPD Model Rats and Its Impact on Serum IL-6 Levels.

  • Published In: Medicinal Plant, 2025, v. 16, n. 6. P. 69 1 of 3

  • Database: Academic Search Ultimate 2 of 3

  • Authored By: LI, Haoyang; LIU, Xingyu; LIANG, Xiaomei; PAN, Lixuan; ZHAO, Liting; YAN, Canxin; LI, Yanyang; SU, Liangna; HUANG, Xiaoyi; HUANG, Suoyi; CHEN, Ran 3 of 3

Abstract

[Objectives] To explore the therapeutic effects of doxofylline combined with Erchen decoction in chronic obstructive pulmonary disease (COPD) model rats and its impact on serum IL-6 levels. [Methods] Rats were divided into seven groups; blank, model, Erchen decoction, doxofylline, and combined medication groups at low, medium, and high doses. After successful modeling, they were administrated intragastrically at the respective doses for4 weeks. [Results] Compared to the control group, serum IL-6 levels in the Erchen decoction group and the combined medication groups at low and medium doses were significantly decreased (P <0.05). Additionally, the body weight of rats after treatment was significantly increased compared to before treatment (P <0.05). [Conclusions] Doxofylline combined with Erchen decoction can reduce serum IL-6 levels in COPD rats, improve their body weight, and exert a therapeutic effect on COPD. [ABSTRACT FROM AUTHOR]

Additional Information

  • Source:Medicinal Plant. 2025/12, Vol. 16, Issue 6, p69
  • Document Type:Article
  • Subject Area:Health and Medicine
  • Publication Date:2025
  • ISSN:2152-3924
  • DOI:10.19600/j.cnki.issn2152-3924.2025.06.014
  • Accession Number:191098798
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