JOURNAL ARTICLE

Global withdrawal of Sabin oral poliovirus type 2 vaccine in 2016.

  • Published In: Science, 2025, v. 387, n. 6738. P. 1042 1 of 3

  • Database: Academic Search Ultimate 2 of 3

  • Authored By: Molodecky, Natalia A.; Sutter, Roland W. 3 of 3

Abstract

Live Sabin oral poliovirus vaccine (OPV), a live-attenuated vaccine, is genetically unstable and can revert back to neurovirulence and transmissibility, causing vaccine-associated paralytic poliomyelitis (VAPP) and circulating vaccine-derived poliovirus (cVDPV). Following a resolution of the World Health Assembly (WHA) in 2015, the Global Polio Eradication Initiative (GPEI) set the target for global withdrawal of the type 2 component of OPV (OPV2) for April 2016 (i.e., the switch). Within 12 to 18 months after the switch, it became apparent that the GPEI struggled to close out (stop and confirm absence of transmission) cVDPV2 outbreaks from undetected transmission and new emergences from OPV2 use in outbreak control. In 2023, the GPEI began discussing the global cessation of all Sabin polioviruses, necessitating the discontinuation of bivalent (type 1 and 3) OPV (i.e., bOPV). We attempt to identify and highlight the causes for the post-switch epidemiologic situation and offer some suggestions on how to avert such a development in the future. [ABSTRACT FROM AUTHOR]

Additional Information

  • Source:Science. 2025/03, Vol. 387, Issue 6738, p1042
  • Document Type:Article
  • Subject Area:Health and Medicine
  • Publication Date:2025
  • ISSN:0036-8075
  • DOI:10.1126/science.adu6580
  • Accession Number:188103638
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