JOURNAL ARTICLE

The effect of morphine in the development of neonatal cholestasis in extremely preterm neonates.

  • Published In: Journal of Neonatal - Perinatal Medicine, 2025, v. 18, n. 4. P. 350 1 of 3

  • Database: Academic Search Ultimate 2 of 3

  • Authored By: Abdelwahab, AH; Abdullah, LO; Mohammed, N; Alikunju, MRP; Abdul Rouf, PV; Thomas, B; Sree, B; Elkassem, WM 3 of 3

Abstract

This article focuses on the relationship between morphine use and liver function in preterm neonates. A retrospective study of 133 preterm infants on mechanical ventilation found that those who received morphine had significantly higher peak levels of liver enzymes (AST) and bilirubin (direct and total) compared to those who did not, suggesting potential morphine-induced hepatotoxicity. The study also observed that liver function test abnormalities were more pronounced in neonates with gestational age ≥30 weeks. The findings highlight the need for cautious use and close monitoring of morphine in preterm neonates to mitigate risks of cholestasis and liver injury, while acknowledging limitations such as retrospective design and confounding factors like total parenteral nutrition.

Additional Information

  • Source:Journal of Neonatal - Perinatal Medicine. 2025/07, Vol. 18, Issue 4, p350
  • Document Type:Article
  • Subject Area:Health and Medicine
  • Publication Date:2025
  • ISSN:1934-5798
  • DOI:10.1177/19345798251336731
  • Accession Number:186103491
  • Copyright Statement:Copyright of Journal of Neonatal - Perinatal Medicine is the property of Sage Publications Inc. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

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