JOURNAL ARTICLE

Researchers from Heinrich-Heine-University Dusseldorf Report Details of New Studies and Findings in the Area of Schizophrenia [Pharmacological rescue of social deficits in rats featuring Disrupted-in-Schizophrenia-1 (DISC1) protein aggregation].

Published In: Mental Health Weekly Digest, 2026. P. 4290 1 of 2
Database: Psychology Source 2 of 2

Abstract

The article focuses on recent research from Heinrich-Heine-University in Dusseldorf, Germany, addressing the pharmacological treatment of negative symptoms in schizophrenia, particularly impairments in social functioning. The study utilized a translational model, the tgDISC1 rat, to investigate the neurobiological basis of these behavioral impairments linked to the Disrupted-in-Schizophrenia-1 (DISC1) gene. Findings indicated that the atypical antipsychotic amisulpride effectively restored social adaptability deficits in tgDISC1 rats, while clozapine did not show similar effects. The research underscores the potential of precision psychiatry in identifying specific biological markers and developing targeted therapies for schizophrenia. [Extracted from the article]

Additional Information

Source:Mental Health Weekly Digest. 2026/02, p4290
Document Type:Article
Subject Area:Health and Medicine
Publication Date:2026
ISSN:1543-6616
Accession Number:191544207
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