Construction of a Prognostic Nomogram for Major Amputation Within 30 Days Postrevascularization in Patients With Acute Lower Limb Ischemia Based on 2D Perfusion Parameters.

The article focuses on developing a prediction model for major amputation (MA) within 30 days after arterial revascularization (AR) in patients with acute lower limb ischemia (ALLI) using two-dimensional (2D) perfusion imaging parameters. In a retrospective study of 310 ALLI patients, skin speckle, myoglobin level, and time-to-peak (TTP) from 2D perfusion imaging were identified as independent risk factors for MA, while atrial fibrillation was found to be protective. A nomogram incorporating these variables demonstrated superior predictive accuracy compared to the traditional Rutherford classification system, showing good discrimination, calibration, and clinical utility. This model offers a novel tool for risk stratification and may guide more informed clinical decision-making in managing ALLI patients postrevascularization.