Oncology Drug Reference Sheet: Cyclophosphamide.

The article focuses on cyclophosphamide, an alkylating agent used in cancer treatment and certain pediatric kidney disorders. It details cyclophosphamide’s mechanism of action, indications—including various lymphomas, leukemias, breast and ovarian cancers, and minimal change nephrotic syndrome in children—and administration routes (intravenous and oral). The summary highlights significant warnings such as myelosuppression, immunosuppression, cardiotoxicity, embryofetal toxicity, infertility, pulmonary toxicity, secondary malignancies, and veno-occlusive liver disease, along with common adverse reactions like neutropenia, nausea, and bladder toxicity. Nursing considerations emphasize monitoring blood counts, organ function, hydration, and patient education on side effects, safe handling, and contraception during and after treatment.