JOURNAL ARTICLE

Findings from Hirokuni Negishi and Co-Authors Broaden Understanding of Down Syndrome (Genetic and Molecular Insights into the Links Between Heat Stroke, Alzheimer's Disease, and Down Syndrome: A Mini-Review).

  • Published In: Mental Health Weekly Digest, 2025. P. 530 1 of 2

  • Database: Psychology Source 2 of 2

Abstract

The article discusses research findings from Toyonaka, Japan, highlighting the relationship between heat stroke and the development or exacerbation of dementia disorders, particularly Alzheimer's disease. It notes that heat stroke is linked to increased expression of the amyloid-beta precursor protein gene, which is significant in both Alzheimer's and Down syndrome, a common chromosomal abnormality associated with dementia. The research suggests that heat stroke poses a dual risk for individuals with Down syndrome, potentially accelerating intellectual decline in addition to being life-threatening. [Extracted from the article]

Additional Information

  • Source:Mental Health Weekly Digest. 2025/11, p530
  • Document Type:Article
  • Subject Area:Health and Medicine
  • Publication Date:2025
  • ISSN:1543-6616
  • Accession Number:189163395
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