JOURNAL ARTICLE

Natural Antibodies Mediate Protection Against Acinetobacter baumannii Respiratory Infections.

  • Published In: Journal of Infectious Diseases, 2023, v. 228, n. 3. P. 353 1 of 3

  • Database: Academic Search Ultimate 2 of 3

  • Authored By: Islam, Aminul; Actis, Luis A; Wilson, Timothy J 3 of 3

Abstract

This article focuses on the role of natural antibodies (NAbs) in mediating innate immune resistance against Acinetobacter baumannii, a multidrug-resistant bacterial pathogen causing severe infections. Using a mouse pneumonia model, the study demonstrates that B- and T-cell–deficient (Rag2−/−) mice exhibit impaired bacterial clearance, which can be rescued by administration of normal mouse serum or purified NAbs. The protective effect of NAbs involves activation of the classical complement pathway, evidenced by increased C3 complement protein deposition on A. baumannii and enhanced opsonophagocytosis by macrophages. These findings suggest that NAbs contribute to early host defense against A. baumannii and may inform development of novel immunotherapies for infections caused by antibiotic-resistant strains.

Additional Information

  • Source:Journal of Infectious Diseases. 2023/08, Vol. 228, Issue 3, p353
  • Document Type:Article
  • Subject Area:Health and Medicine
  • Publication Date:2023
  • ISSN:0022-1899
  • DOI:10.1093/infdis/jiad069
  • Accession Number:170047714
  • Copyright Statement:Copyright of Journal of Infectious Diseases is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

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