JOURNAL ARTICLE

Extending the reach of a classic oncogene.

  • Published In: Science, 2026, v. 391, n. 6790. P. 1103 1 of 3

  • Database: Academic Search Ultimate 2 of 3

  • Authored By: Pfannenstein, Alexander; Meyer, Tobias 3 of 3

Abstract

The cellular kinase Src (or c-Src) plays a role in adhesion, motility, and proliferation. In cancers, its expression and activity are commonly increased, underscoring its pivotal role in sustaining malignant phenotypes across tumor types (1). On page 1124 of this issue, Delaveris et al. (2) report that many cancer cells with high Src expression also produce extracellular Src (e-Src) that is delivered to the extracellular-facing cell surface. Moreover, this exposed e-Src was effectively targeted by immunotherapy in preclinical tumor models. The finding highlights an attractive therapeutic avenue because Src is not typically found on the outer layer of the plasma membrane. [ABSTRACT FROM AUTHOR]

Additional Information

  • Source:Science. 2026/03, Vol. 391, Issue 6790, p1103
  • Document Type:Article
  • Subject Area:Health and Medicine
  • Publication Date:2026
  • ISSN:0036-8075
  • DOI:10.1126/science.aef9956
  • Accession Number:192262969
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