An infant with achondroplasia worsening of the foramen magnum stenosis during early vosoritide treatment.

  • Published In: Pediatrics International, 2025, v. 67, n. 1. P. 1 1 of 3

  • Database: Academic Search Ultimate 2 of 3

  • Authored By: Gunji, Yuki; Aoki, Ryoji; Nagano, Nobuhiko; Aoki, Masako; Okahashi, Aya; Sumi, Koichiro; Morioka, Ichiro 3 of 3

Abstract

The article focuses on a case study of an infant with achondroplasia (ACH) who experienced worsening foramen magnum stenosis (FMS) despite early treatment with vosoritide, a medication aimed at stimulating endochondral ossification. The patient, a 2-month-old girl diagnosed with ACH due to a pathogenic variant in the FGFR3 gene, showed favorable growth in height after starting vosoritide but developed severe FMS, necessitating foramen magnum decompression (FMD). The findings suggest that while vosoritide may improve growth, it does not prevent the progression of FMS, highlighting the need for careful monitoring through brain MRI. The study emphasizes the complexity of managing ACH and the potential challenges associated with early treatment. [Extracted from the article]

Additional Information

  • Source:Pediatrics International. 2025/01, Vol. 67, Issue 1, p1
  • Document Type:Article
  • Subject Area:Health and Medicine
  • Publication Date:2025
  • ISSN:1328-8067
  • DOI:10.1111/ped.70089
  • Accession Number:190445139
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