Intravenous Glutathione and Vitamin Supplementation Causing Stevens–Johnson Syndrome: A Case Report.

This article focuses on a case of Stevens–Johnson syndrome/toxic epidermal necrolysis (SJS/TEN) potentially triggered by an intravenous (IV) vitamin infusion containing glutathione, vitamin C, and vitamin D administered at a wellness center. SJS/TEN are severe mucocutaneous hypersensitivity reactions most commonly caused by prescription medications, but this case highlights the possible role of IV glutathione, which has been previously implicated and prompted warnings by the Republic of the Philippines' FDA. The report underscores the increasing use of unregulated IV vitamin infusions in the United States and the importance for clinicians to thoroughly review patients' histories, including alternative therapies, to identify potential SJS/TEN triggers. Management of SJS/TEN remains primarily supportive, with emerging interest in tumor necrosis factor-α inhibitors like etanercept as adjunctive therapy.