Mistletoe for Bladder Cancer: Call for More Case Reports Using the Intravesical Route.

The article comments on a case report by D. Davis et al on complete remission of Bacillus Calmette-Guerin-refractory high-grade bladder carcinoma in situ with pharmacologic ascorbate and mistletoe treatments. Topics include the remarkable progress reported in patients incorporating various modalities of mistletoe extract (ME) treatment together with chemotherapy, the potential cell-signaling properties of ME, and the high recurrence rate of non-muscle-involved bladder cancer in older adults.