JOURNAL ARTICLE

Delayed Pressure Urticaria Associated With Altitude Chamber Training Responsive to Cyclosporine and Omalizumab.

  • Published In: Military Medicine, 2024, v. 189, n. 11/12. P. 2710 1 of 3

  • Database: Academic Search Ultimate 2 of 3

  • Authored By: Alix, Veronica C; Weiss, Samuel L; White, Kevin M 3 of 3

Abstract

This article focuses on a case report of delayed pressure urticaria (DPU), a subtype of chronic inducible urticaria characterized by wheal formation 30 minutes to 24 hours after localized pressure. It describes a military flight crew member who developed DPU following rapid decompression during altitude chamber training, with symptoms refractory to antihistamine monotherapy. Symptom control was achieved through combination therapy including a second-generation antihistamine, leukotriene receptor antagonist, and immunosuppressant cyclosporine, followed by successful management with omalizumab, a monoclonal antibody targeting free immunoglobulin E. The case highlights the challenges in diagnosing and treating DPU, the potential role of altitude changes as a trigger, and the use of advanced therapies to enable return to active duty.

Additional Information

  • Source:Military Medicine. 2024/11, Vol. 189, Issue 11/12, p2710
  • Document Type:Article
  • Subject Area:Health and Medicine
  • Publication Date:2024
  • ISSN:0026-4075
  • DOI:10.1093/milmed/usae333
  • Accession Number:180763943
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