Findings from Gulhane Training and Research Hospital Provide New Insights into Autism Spectrum Disorders (Familial co-occurrence of autism spectrum disorder and 47 XYY syndrome: revisiting the role of Y chromosome dosage in neurodevelopment).

This article focuses on a rare familial case reported from Ankara, Turkey, involving two brothers: one diagnosed with autism spectrum disorder (ASD) meeting DSM-5 Level 3 criteria, and the other with a 47 XYY karyotype exhibiting subthreshold autistic traits. The research, conducted at Gulhane Training and Research Hospital, explores the potential influence of Y chromosome dosage, particularly Y-linked genes like NLGN4Y, on neurodevelopment and male-specific genetic vulnerability to ASD. Both siblings received individualized education and pharmacologic support, highlighting the importance of early screening and multidisciplinary interventions for at-risk individuals even without full syndromic presentation. This peer-reviewed study contributes to the limited literature on the genetic interplay between ASD and XYY syndrome. [Extracted from the article]