JOURNAL ARTICLE

Ganoderma lucidum triterpenoids investigating their role in medicinal applications and genomic protection.

  • Published In: Journal of Pharmacy & Pharmacology, 2024, v. 76, n. 12. P. 1535 1 of 3

  • Database: Academic Search Ultimate 2 of 3

  • Authored By: Raza, Sayed Haidar Abbas; Zhong, Ruimin; Li, Xiangmei; Pant, Sameer D; Shen, Xing; BinMowyna, Mona N; Luo, Lin; Lei, Hongtao 3 of 3

Abstract

This article focuses on the triterpenoids isolated from Ganoderma lucidum (GL), a medicinal white rot fungus, detailing their chemical structures, biosynthesis pathways, and diverse pharmacological properties. Triterpenoids from GL, primarily lanostane-type compounds, exhibit multiple therapeutic effects including antimicrobial, antiviral, antiparasitic, anti-inflammatory, anticancer, and antihyperlipidemic activities. They also function as genomic guardians by protecting DNA from radiation-induced damage and enhancing DNA repair mechanisms. The review emphasizes the potential of GL triterpenoids as bioactive agents in functional foods, nutraceuticals, and complementary therapies, while noting the need for further clinical research to standardize extracts and validate safety and efficacy.

Additional Information

  • Source:Journal of Pharmacy & Pharmacology. 2024/12, Vol. 76, Issue 12, p1535
  • Document Type:Article
  • Subject Area:Health and Medicine
  • Publication Date:2024
  • ISSN:0022-3573
  • DOI:10.1093/jpp/rgae133
  • Accession Number:181987130
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