Dietary factors in Helicobacter pylori infection control: A review of in vitro and in vivo data, including case-controls.

This article focuses on the potential of seven non-antibiotic agents (NAAs)—including cranberry, green tea, Nigella sativa, microalgae (Arthrospira spp.), propolis, honey, curcumin, and broccoli—to combat Helicobacter pylori infection, a class I carcinogen strongly linked to gastric cancer and lymphoma. The review summarizes evidence of these agents’ anti-inflammatory, antibacterial, anti-adhesive, anti-ulcer, anti-urease, and anti-cancer properties, highlighting their possible roles as adjuncts to conventional antibiotic therapies amid rising antibiotic resistance. Clinical and experimental studies indicate that some NAAs, such as cranberry, Nigella sativa, broccoli, and curcumin, may improve eradication rates or provide gastroprotective effects, though further research is needed to establish optimal dosing, safety, and potential drug interactions. The article underscores the importance of cautious use due to factors like bioavailability, side effects, and quality control, and suggests that NAAs could contribute to both treatment and prophylaxis of H. pylori infection within a broader health context.