JOURNAL ARTICLE

Many Individuals With Pathogenic Breast Cancer Genetic Variants Are Being Missed by Current Testing Guidelines.

  • Published In: ONS Voice, 2026. P. N.PAG 1 of 3

  • Database: Academic Search Ultimate 2 of 3

  • Authored By: Snively, Anne 3 of 3

Abstract

The article focuses on findings from the Women Informed to Screen Depending on Measures of Risk (WISDOM) trial, which examined the prevalence of germline pathogenic variants linked to breast cancer among females aged 40–74 without a breast cancer diagnosis. Out of 23,098 participants, 3.1% (714) had such variants, with 605 unaware of their status; notably, 30% of those unaware did not meet current genetic testing eligibility criteria. Current guidelines for genetic testing consider factors like family history of breast or ovarian cancer and Jewish ancestry, but the study suggests these criteria may miss a significant portion of individuals at risk. These results highlight potential gaps in genetic screening practices for breast cancer risk assessment.

Additional Information

  • Source:ONS Voice. 2026/03, pN.PAG
  • Document Type:Article
  • Subject Area:Health and Medicine
  • Publication Date:2026
  • ISSN:2475-6938
  • Accession Number:192824448
  • Copyright Statement:Copyright of ONS Voice is the property of Oncology Nursing Society and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Looking to go deeper into this topic? Look for more articles on EBSCOhost.