JOURNAL ARTICLE

HLA investigation in ICI-induced T1D and isolated ACTH deficiency including meta-analysis.

  • Published In: European Journal of Endocrinology, 2024, v. 191, n. 1. P. 9 1 of 3

  • Database: Academic Search Ultimate 2 of 3

  • Authored By: Ono, Mayo; Nagao, Mototsugu; Takeuchi, Haruki; Fukunaga, Etsuya; Nagamine, Tomoko; Inagaki, Kyoko; Fukuda, Izumi; Iwabu, Masato 3 of 3

Abstract

This article focuses on the analysis of human leukocyte antigen (HLA) signatures associated with immune checkpoint inhibitor (ICI)-induced type 1 diabetes (ICI-T1D) and isolated adrenocorticotropic hormone deficiency (ICI-IAD) in Japanese patients. The study found that specific HLAs, including HLA-DRB1*09:01-DQB1*03:03 and DRB1*13:02-DQB1*06:04, are linked to susceptibility to ICI-T1D, while DRB1*15:02-DQB1*06:01 is protective against ICI-T1D but associated with susceptibility to ICI-IAD. Notably, the protective haplotype DRB1*15:02-DQB1*06:01 was absent in patients with both ICI-T1D and ICI-IAD, suggesting it may prevent the co-occurrence of these conditions. These findings contribute to understanding genetic risk factors for endocrine adverse events in patients undergoing ICI therapy.

Additional Information

  • Source:European Journal of Endocrinology. 2024/07, Vol. 191, Issue 1, p9
  • Document Type:Article
  • Subject Area:Health and Medicine
  • Publication Date:2024
  • ISSN:0804-4643
  • DOI:10.1093/ejendo/lvae081
  • Accession Number:178778953
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