JOURNAL ARTICLE

Slight hyperintensity of the left piriform cortex and amygdala on T2-weighted FLAIR images in older adults and patients with probable Alzheimer's disease.

  • Published In: Acta Radiologica, 2025, v. 66, n. 8. P. 816 1 of 3

  • Database: Academic Search Ultimate 2 of 3

  • Authored By: Ishizaka, Hiroshi; Sekine, Akiko; Naka, Minoru; Nakano, Saeki; Nagase, Hiroyuki; Tsushima, Yoshito 3 of 3

Abstract

This article focuses on the quantitative assessment of signal intensity (SI) changes in the left piriform cortex and amygdala (PC&A) on T2-weighted fluid-attenuated inversion recovery (T2W-FLAIR) magnetic resonance images in relation to aging and probable Alzheimer's disease (pAD). The study retrospectively analyzed SI ratios in younger controls, older controls without cognitive impairment, and pAD patients, finding a significant increase in left PC&A SI with age and in pAD, while the right PC&A showed no such change. These findings suggest that increased left PC&A SI may reflect neuroinflammatory deterioration associated with aging and early AD pathology. The study highlights the potential of left PC&A SI changes as an imaging biomarker for aging-related and AD-related brain changes, though it notes limitations including the retrospective design and the need for longitudinal studies.

Additional Information

  • Source:Acta Radiologica. 2025/08, Vol. 66, Issue 8, p816
  • Document Type:Article
  • Subject Area:Health and Medicine
  • Publication Date:2025
  • ISSN:0284-1851
  • DOI:10.1177/02841851251328261
  • Accession Number:187242532
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